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Progress in Establishment of Endometriosis in Vitro Histological Models

Received: 26 December 2018     Published: 27 December 2018
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Abstract

The etiology and pathogenesis of endometriosis are hotspots in the field of obstetrics and gynecology today.With the rapid development of experimental studies of endometriosis, the establishment of in vitro histological models is increasingly important.The establishment and application of in vitro histological model provides a new research platform for exploring the pathogenesis and treatment of endometriosis. It is an important method to study endometriosis. Recently a variety of models have been successfully constructed, but still have many deficiencies. Up to now, studies on in vitro histological models have been qualitative, and no studies have involved quantitative analysis. Whether peritoneal mesothelial defect is the cause or result of adhesion, that is, peritoneal mesothelial defect itself exists in the patient, or the damage of the mesothelial during operation, or the destruction of the mesothelial by some cytokines secreted by implanted endometrial tissue? These problems have not yet been decided. Therefore, the choice of appropriate histological model to establish a method is conducive to further reveal the etiology of endometriosis, pathogenesis and evaluation of treatment. This paper reviews the research progress about the development of endometriosis with establishment of in vitro histological models, to further explore the best and stable culture conditions of human endometriosis histological model, and to establish a good model basis for further study of endometriosis.

Published in Science Discovery (Volume 6, Issue 6)
DOI 10.11648/j.sd.20180606.37
Page(s) 551-554
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Endometriosis, Establishment of Vitro Histological Models, Research Progress

References
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    Ma Di. (2018). Progress in Establishment of Endometriosis in Vitro Histological Models. Science Discovery, 6(6), 551-554. https://doi.org/10.11648/j.sd.20180606.37

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    Ma Di. Progress in Establishment of Endometriosis in Vitro Histological Models. Sci. Discov. 2018, 6(6), 551-554. doi: 10.11648/j.sd.20180606.37

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    Ma Di. Progress in Establishment of Endometriosis in Vitro Histological Models. Sci Discov. 2018;6(6):551-554. doi: 10.11648/j.sd.20180606.37

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  • @article{10.11648/j.sd.20180606.37,
      author = {Ma Di},
      title = {Progress in Establishment of Endometriosis in Vitro Histological Models},
      journal = {Science Discovery},
      volume = {6},
      number = {6},
      pages = {551-554},
      doi = {10.11648/j.sd.20180606.37},
      url = {https://doi.org/10.11648/j.sd.20180606.37},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20180606.37},
      abstract = {The etiology and pathogenesis of endometriosis are hotspots in the field of obstetrics and gynecology today.With the rapid development of experimental studies of endometriosis, the establishment of in vitro histological models is increasingly important.The establishment and application of in vitro histological model provides a new research platform for exploring the pathogenesis and treatment of endometriosis. It is an important method to study endometriosis. Recently a variety of models have been successfully constructed, but still have many deficiencies. Up to now, studies on in vitro histological models have been qualitative, and no studies have involved quantitative analysis. Whether peritoneal mesothelial defect is the cause or result of adhesion, that is, peritoneal mesothelial defect itself exists in the patient, or the damage of the mesothelial during operation, or the destruction of the mesothelial by some cytokines secreted by implanted endometrial tissue? These problems have not yet been decided. Therefore, the choice of appropriate histological model to establish a method is conducive to further reveal the etiology of endometriosis, pathogenesis and evaluation of treatment. This paper reviews the research progress about the development of endometriosis with establishment of in vitro histological models, to further explore the best and stable culture conditions of human endometriosis histological model, and to establish a good model basis for further study of endometriosis.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - Progress in Establishment of Endometriosis in Vitro Histological Models
    AU  - Ma Di
    Y1  - 2018/12/27
    PY  - 2018
    N1  - https://doi.org/10.11648/j.sd.20180606.37
    DO  - 10.11648/j.sd.20180606.37
    T2  - Science Discovery
    JF  - Science Discovery
    JO  - Science Discovery
    SP  - 551
    EP  - 554
    PB  - Science Publishing Group
    SN  - 2331-0650
    UR  - https://doi.org/10.11648/j.sd.20180606.37
    AB  - The etiology and pathogenesis of endometriosis are hotspots in the field of obstetrics and gynecology today.With the rapid development of experimental studies of endometriosis, the establishment of in vitro histological models is increasingly important.The establishment and application of in vitro histological model provides a new research platform for exploring the pathogenesis and treatment of endometriosis. It is an important method to study endometriosis. Recently a variety of models have been successfully constructed, but still have many deficiencies. Up to now, studies on in vitro histological models have been qualitative, and no studies have involved quantitative analysis. Whether peritoneal mesothelial defect is the cause or result of adhesion, that is, peritoneal mesothelial defect itself exists in the patient, or the damage of the mesothelial during operation, or the destruction of the mesothelial by some cytokines secreted by implanted endometrial tissue? These problems have not yet been decided. Therefore, the choice of appropriate histological model to establish a method is conducive to further reveal the etiology of endometriosis, pathogenesis and evaluation of treatment. This paper reviews the research progress about the development of endometriosis with establishment of in vitro histological models, to further explore the best and stable culture conditions of human endometriosis histological model, and to establish a good model basis for further study of endometriosis.
    VL  - 6
    IS  - 6
    ER  - 

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Author Information
  • Obstetrics and Gynecology Department, First Affiliated Hospital of Harbin Medical University, Harbin, China

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