| Peer-Reviewed

Experimental Study on Autism Caused by Prenatal Exposure to Plasticizer DEHP

Received: 5 March 2019     Published: 23 May 2019
Views:       Downloads:
Abstract

Objective: Epidemiological studies have found that exposure to plasticizers in the environment may be associated with autism in preschool children, but laboratory evidence is lacking. To determine whether prenatal exposure to DEHP, a plasticizer, causes autism in offspring mice. Methods: Pregnant mice were randomly divided into four groups: corn oil control group and low, medium and high concentration DEHP exposure group (10 mg/kg, 50 mg/kg, 250 mg/kg). Mice were received continuous intragastric administration of DEHP from the 3rd day to the 17th day of pregnancy. Behavioral characteristics of autism in offspring were assessed after birth. Results: The social ability of offspring was significantly decreased after prenatal exposure to moderate and high concentration DEHP. The female offspring showed repetitive stereotyped behavior and decreased spontaneous activities. Conclusion: Exposure to medium and high concentration of DEHP during embryonic stage can induce autism in offsprings.

Published in Science Discovery (Volume 7, Issue 2)
DOI 10.11648/j.sd.20190702.14
Page(s) 78-81
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Di(2-ethylhexyl)phthalate, Autism Spectrum Disorder, Neurodevelopment

References
[1] 仇子龙. 自闭症的神经生物学研究 科学, 2015,67(6):20-23.
[2] Tchaconas A, Adesman A. Autistic Spectrum Disorder. Current Opinion in Pediatrics, 2013,25(1):130-144.
[3] Nuttall J R. The plausibility of maternal toxicant exposure and nutritional status as contributing factors to the risk of autism spectrum disorders. Nutr Neurosci, 2017,20(4):209-218.
[4] Testa C, Nuti F, Hayek J, De Felice C, Chelli M, Rovero P, Latini G, Papini A M. Di-(2-ethylhexyl) phthalate and autism spectrum disorders. ASN Neuro, 2012,4(4):223-229.
[5] 王永俊, 李永宁, 马宁, 贾旭东. DEHP暴露对子代大鼠空间学习记忆能力和海马突触可塑性相关蛋白基因表达的影响. 中国食品卫生杂志. 2015,27(3):237-241.
[6] 徐晓虹, 竹庆杰, 杨艳玲, 阮琴. 出生前后DEHP暴露对小鼠神经行为的影响. 浙江师范大学学报(自然科学版).2015,38(1):15-22.
[7] 徐晓虹, 沈超, 周易, 秦泽旭, 梅成龙, 施剑. 增塑剂DEHP的发育和神经毒性研究进展. 浙江师范大学学报(自然科学版) 2013,2:209-212.
[8] Bang du Y, Lee I K, Lee B M. Toxicological characterization of phthalic Acid. Toxicol Res, 2011,27(4):191-203.
[9] Jeddi M Z, Janani L, Memari A H, Akhondzadeh S, Yunesian M. The role of phthalate esters in autism development: A systematic review. Environ Res, 2016,151:493-504.
[10] Lin H, Yuan K, Li L, Liu S, Li S, Hu G, Lian Q Q, Ge R S. In Utero Exposure to Diethylhexyl Phthalate Affects Rat Brain Development: A Behavioral and Genomic Approach. Int J Environ Res Public Health, 2015,12(11):13696-13710.
[11] Li X J, Jiang L, Chen L, Chen H S, Li X. Neurotoxicity of dibutyl phthalate in brain development following perinatal exposure: a study in rats. Environ Toxicol Pharmacol, 2013,36(2):392-402.
[12] Abbott N J. Blood-brain barrier structure and function and the challenges for CNS drug delivery. J Inherit Metab Dis, 2013,36(3):437-449.
[13] Kalisch-Smith J I, Simmons D G, Pantaleon M, Moritz K M. Sex differences in rat placental development: from pre-implantation to late gestation. Biol Sex Differ, 2017,8:17.
[14] Masuo Y, Morita M, Oka S, Ishido M. Motor hyperactivity caused by a deficit in dopaminergic neurons and the effects of endocrine disruptors: a study inspired by the physiological roles of PACAP in the brain. Regul Pept, 2004,123(1-3):225-234.
[15] Engel S M, Miodovnik A, Canfield R L, Zhu C, Silva M J, Calafat A M, Wolff M S. Prenatal phthalate exposure is associated with childhood behavior and executive functioning. Environ Health Perspect, 2010,118(4):565-571.
Cite This Article
  • APA Style

    Boyang Hu, Yiting Song, Genan Liang, Yihuan Shao, Linling Qi, et al. (2019). Experimental Study on Autism Caused by Prenatal Exposure to Plasticizer DEHP. Science Discovery, 7(2), 78-81. https://doi.org/10.11648/j.sd.20190702.14

    Copy | Download

    ACS Style

    Boyang Hu; Yiting Song; Genan Liang; Yihuan Shao; Linling Qi, et al. Experimental Study on Autism Caused by Prenatal Exposure to Plasticizer DEHP. Sci. Discov. 2019, 7(2), 78-81. doi: 10.11648/j.sd.20190702.14

    Copy | Download

    AMA Style

    Boyang Hu, Yiting Song, Genan Liang, Yihuan Shao, Linling Qi, et al. Experimental Study on Autism Caused by Prenatal Exposure to Plasticizer DEHP. Sci Discov. 2019;7(2):78-81. doi: 10.11648/j.sd.20190702.14

    Copy | Download

  • @article{10.11648/j.sd.20190702.14,
      author = {Boyang Hu and Yiting Song and Genan Liang and Yihuan Shao and Linling Qi and Xue Jiang and Yuemin Ding},
      title = {Experimental Study on Autism Caused by Prenatal Exposure to Plasticizer DEHP},
      journal = {Science Discovery},
      volume = {7},
      number = {2},
      pages = {78-81},
      doi = {10.11648/j.sd.20190702.14},
      url = {https://doi.org/10.11648/j.sd.20190702.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20190702.14},
      abstract = {Objective: Epidemiological studies have found that exposure to plasticizers in the environment may be associated with autism in preschool children, but laboratory evidence is lacking. To determine whether prenatal exposure to DEHP, a plasticizer, causes autism in offspring mice. Methods: Pregnant mice were randomly divided into four groups: corn oil control group and low, medium and high concentration DEHP exposure group (10 mg/kg, 50 mg/kg, 250 mg/kg). Mice were received continuous intragastric administration of DEHP from the 3rd day to the 17th day of pregnancy. Behavioral characteristics of autism in offspring were assessed after birth. Results: The social ability of offspring was significantly decreased after prenatal exposure to moderate and high concentration DEHP. The female offspring showed repetitive stereotyped behavior and decreased spontaneous activities. Conclusion: Exposure to medium and high concentration of DEHP during embryonic stage can induce autism in offsprings.},
     year = {2019}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Experimental Study on Autism Caused by Prenatal Exposure to Plasticizer DEHP
    AU  - Boyang Hu
    AU  - Yiting Song
    AU  - Genan Liang
    AU  - Yihuan Shao
    AU  - Linling Qi
    AU  - Xue Jiang
    AU  - Yuemin Ding
    Y1  - 2019/05/23
    PY  - 2019
    N1  - https://doi.org/10.11648/j.sd.20190702.14
    DO  - 10.11648/j.sd.20190702.14
    T2  - Science Discovery
    JF  - Science Discovery
    JO  - Science Discovery
    SP  - 78
    EP  - 81
    PB  - Science Publishing Group
    SN  - 2331-0650
    UR  - https://doi.org/10.11648/j.sd.20190702.14
    AB  - Objective: Epidemiological studies have found that exposure to plasticizers in the environment may be associated with autism in preschool children, but laboratory evidence is lacking. To determine whether prenatal exposure to DEHP, a plasticizer, causes autism in offspring mice. Methods: Pregnant mice were randomly divided into four groups: corn oil control group and low, medium and high concentration DEHP exposure group (10 mg/kg, 50 mg/kg, 250 mg/kg). Mice were received continuous intragastric administration of DEHP from the 3rd day to the 17th day of pregnancy. Behavioral characteristics of autism in offspring were assessed after birth. Results: The social ability of offspring was significantly decreased after prenatal exposure to moderate and high concentration DEHP. The female offspring showed repetitive stereotyped behavior and decreased spontaneous activities. Conclusion: Exposure to medium and high concentration of DEHP during embryonic stage can induce autism in offsprings.
    VL  - 7
    IS  - 2
    ER  - 

    Copy | Download

Author Information
  • Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou, China

  • Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou, China

  • Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou, China

  • Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou, China

  • Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou, China

  • Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou, China

  • Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou, China

  • Sections